{"id":4,"date":"2014-06-20T15:57:49","date_gmt":"2014-06-20T19:57:49","guid":{"rendered":"http:\/\/umaine.edu\/wheelerlab\/?page_id=2"},"modified":"2025-07-02T12:38:14","modified_gmt":"2025-07-02T16:38:14","slug":"home","status":"publish","type":"page","link":"https:\/\/umaine.edu\/wheelerlab\/","title":{"rendered":"Home"},"content":{"rendered":"<style>.kb-row-layout-id4_3c7e10-80 > .kt-row-column-wrap{align-content:start;}:where(.kb-row-layout-id4_3c7e10-80 > .kt-row-column-wrap) > .wp-block-kadence-column{justify-content:start;}.kb-row-layout-id4_3c7e10-80 > .kt-row-column-wrap{column-gap:var(--global-kb-gap-md, 2rem);row-gap:var(--global-kb-gap-md, 2rem);padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);grid-template-columns:minmax(0, 2fr) minmax(0, 1fr);}.kb-row-layout-id4_3c7e10-80 > .kt-row-layout-overlay{opacity:0.30;}@media all and (max-width: 1024px){.kb-row-layout-id4_3c7e10-80 > .kt-row-column-wrap{grid-template-columns:minmax(0, 2fr) minmax(0, 1fr);}}@media all and (max-width: 767px){.kb-row-layout-id4_3c7e10-80 > .kt-row-column-wrap{grid-template-columns:minmax(0, 1fr);}}<\/style><div class=\"kb-row-layout-wrap kb-row-layout-id4_3c7e10-80 alignnone wp-block-kadence-rowlayout\"><div class=\"kt-row-column-wrap kt-has-2-columns kt-row-layout-left-golden kt-tab-layout-inherit kt-mobile-layout-row kt-row-valign-top\">\n<style>.kadence-column4_f772c2-04 > .kt-inside-inner-col,.kadence-column4_f772c2-04 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column4_f772c2-04 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column4_f772c2-04 > .kt-inside-inner-col{flex-direction:column;}.kadence-column4_f772c2-04 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column4_f772c2-04 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column4_f772c2-04{position:relative;}@media all and (max-width: 1024px){.kadence-column4_f772c2-04 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column4_f772c2-04 > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column4_f772c2-04\"><div class=\"kt-inside-inner-col\"><style>.wp-block-kadence-advancedheading.kt-adv-heading4_bd1e4c-7b, .wp-block-kadence-advancedheading.kt-adv-heading4_bd1e4c-7b[data-kb-block=\"kb-adv-heading4_bd1e4c-7b\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading4_bd1e4c-7b mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading4_bd1e4c-7b[data-kb-block=\"kb-adv-heading4_bd1e4c-7b\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading4_bd1e4c-7b img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading4_bd1e4c-7b[data-kb-block=\"kb-adv-heading4_bd1e4c-7b\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading4_bd1e4c-7b wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading4_bd1e4c-7b\">Fungal-Host Interaction<\/h2>\n\n\n\n<p>There is an ongoing war between microbial pathogens and their hosts. For each mode of host immunity, the challenger has designed a defense,\u00a0which in turn leads the host to devise a new avenue of attack.\u00a0Opportunistic pathogens such as the fungus\u00a0<em>Candida<\/em>, a leading cause of hospital-acquired infection and an increasingly important killer, must be able to constantly evade the attacks of the host and exploit any break in host defense caused by a compromise of immunity.\u00a0The host, in turn, depends to a large part on innate immune responses to protect itself against this fungus.\u00a0Using high throughput cell biology and genetics, we are elucidating this ongoing battle between fungi and host from both sides of the conflict.<\/p>\n<\/div><\/div>\n\n\n<style>.kadence-column4_7f9eac-ba > .kt-inside-inner-col,.kadence-column4_7f9eac-ba > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column4_7f9eac-ba > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column4_7f9eac-ba > .kt-inside-inner-col{flex-direction:column;}.kadence-column4_7f9eac-ba > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column4_7f9eac-ba > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column4_7f9eac-ba{position:relative;}@media all and (max-width: 1024px){.kadence-column4_7f9eac-ba > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column4_7f9eac-ba > .kt-inside-inner-col{flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column4_7f9eac-ba\"><div class=\"kt-inside-inner-col\"><style>.kb-image4_d8c65e-6b .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image4_d8c65e-6b size-full\"><a href=\"https:\/\/umaine.edu\/wheelerlab\/resource\/umainetoday-article-2013\/\" class=\"kb-advanced-image-link\"><img loading=\"lazy\" decoding=\"async\" width=\"398\" height=\"537\" src=\"https:\/\/umaine.edu\/wheelerlab\/wp-content\/uploads\/sites\/285\/2016\/12\/91福利Today-Image-1.png\" alt=\"A cover image for the 91福利 Today article Battle Lines\" class=\"kb-img wp-image-451\" srcset=\"https:\/\/umaine.edu\/wheelerlab\/wp-content\/uploads\/sites\/285\/2016\/12\/91福利Today-Image-1.png 398w, https:\/\/umaine.edu\/wheelerlab\/wp-content\/uploads\/sites\/285\/2016\/12\/91福利Today-Image-1-222x300.png 222w, https:\/\/umaine.edu\/wheelerlab\/wp-content\/uploads\/sites\/285\/2016\/12\/91福利Today-Image-1-317x428.png 317w\" sizes=\"auto, (max-width: 320px) 85vw, (max-width: 768px) 67vw, (max-width: 1024px) 62vw,398px\" \/><\/a><figcaption>An article about the lab&#8217;s research.<\/figcaption><\/figure>\n<\/div><\/div>\n\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Fungal-Host Interaction There is an ongoing war between microbial pathogens and their hosts. For each mode of host immunity, the challenger has designed a defense,\u00a0which in turn leads the host to devise a new avenue of attack.\u00a0Opportunistic pathogens such as the fungus\u00a0Candida, a leading cause of hospital-acquired infection and an increasingly important killer, must be [&hellip;]<\/p>\n","protected":false},"author":930,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-4","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Home - Wheeler Lab - University of Maine<\/title>\n<meta name=\"description\" content=\"Intravital imaging of fungal-host interaction in zebrafish\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/umaine.edu\/wheelerlab\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Home - 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