{"id":45805,"global_id":"umaine.edu\/medicine?id=45805","global_id_lineage":["umaine.edu\/medicine?id=45805"],"author":"2116","status":"publish","date":"2023-01-17 11:18:46","date_utc":"2023-01-17 16:18:46","modified":"2023-01-17 13:22:27","modified_utc":"2023-01-17 18:22:27","url":"https:\/\/umaine.edu\/medicine\/event\/do-some-over-the-counter-antimicrobials-do-more-harm-than-good-the-unexpected-cellular-and-mitochondrial-toxicity-of-triclosan-and-cetylpyridinium-chloride\/","rest_url":"https:\/\/umaine.edu\/medicine\/wp-json\/tribe\/events\/v1\/events\/45805","title":"Do some over-the-counter antimicrobials do more harm than good? The unexpected cellular and mitochondrial toxicity of triclosan and cetylpyridinium chloride","description":"<p><strong>Speaker:&nbsp;<\/strong>Julie Gosse, Ph.D., Associate Professor of Biochemistry, University of Maine.<\/p>\n<p><strong>91福利 the speaker:&nbsp;<\/strong>Postdoctoral training (2005-2007) Dartmouth Medical School.&nbsp; Ph.D. (2005) Cornell University<\/p>\n<p>Dr. Gosses&#8217;s research interests include biochemical, molecular, biophysical, and cellular toxicology and effects of toxicants on signal transduction pathways and mitochondria.<\/p>\n<p><b>91福利 the seminar:<\/b> A wide swath of humanity is exposed to high concentrations of over-the counter (OTC) antimicrobials via numerous workplace, personal care product, and agricultural applications.&nbsp; Some of these drugs have been in use for decades, even for a century, and were \u201cgrandfathered in\u201d for continual use approval rather than ever being subject to scientific study of their toxicological effects on eukaryotes (including humans).&nbsp; Two of these chemicals include triclosan (TCS) and cetylpyridinium chloride (CPC).&nbsp; The benefits of any widespread, high dose chemical must be weighed with potential risks by gathering toxicology data.&nbsp; CPC may have additional beneficial effects beyond its known antibacterial properties, including anti-influenza and anti-SARS-CoV-2 activities.&nbsp; However, we have discovered adverse effects of both TCS and CPC, at low doses, on mammalian immune cell signaling and mitochondrial function.&nbsp; <i>Ironically, these antibacterial agents, employed to fight microbial disease, may inhibit immune function<\/i>.&nbsp; We have determined the effective dose ranges and underlying molecular mechanisms, which aid in prediction of toxic effects in other systems or with similarly-structured chemicals.&nbsp; Along with other researchers\u2019 data and a raft of epidemiological findings, this research led to the recent banning or removal from TCS from most consumer products.&nbsp; CPC is far less-studied than TCS and remains in numerous OTC products.&nbsp; We employ molecular, biochemical, and biophysical tools, including super-resolution fluorescence microscopy, to unravel the mechanisms by which these chemicals modulate immune cell and mitochondrial function.&nbsp; Our work provides insights into impacts on public health, and will point to either pharmacological uses for or toxic impacts of this ubiquitous chemicals.<\/p>\n<p>This event is free, but <a href=\"https:\/\/maine.zoom.us\/meeting\/register\/tZ0ldu2pqz0tGtOk2YTflcWI2xpciNbvOPdC\">registration<\/a> is required<\/p>","excerpt":"","slug":"do-some-over-the-counter-antimicrobials-do-more-harm-than-good-the-unexpected-cellular-and-mitochondrial-toxicity-of-triclosan-and-cetylpyridinium-chloride","image":false,"all_day":false,"start_date":"2023-02-24 12:00:00","start_date_details":{"year":"2023","month":"02","day":"24","hour":"12","minutes":"00","seconds":"00"},"end_date":"2023-02-24 13:00:00","end_date_details":{"year":"2023","month":"02","day":"24","hour":"13","minutes":"00","seconds":"00"},"utc_start_date":"2023-02-24 17:00:00","utc_start_date_details":{"year":"2023","month":"02","day":"24","hour":"17","minutes":"00","seconds":"00"},"utc_end_date":"2023-02-24 18:00:00","utc_end_date_details":{"year":"2023","month":"02","day":"24","hour":"18","minutes":"00","seconds":"00"},"timezone":"America\/New_York","timezone_abbr":"EST","cost":"Free","cost_details":{"currency_symbol":"","currency_code":"","currency_position":"prefix","values":["0"]},"website":"https:\/\/umaine.edu\/medicine\/seminars-2\/","show_map":false,"show_map_link":false,"hide_from_listings":false,"sticky":false,"featured":false,"categories":[{"name":"Seminar Series","slug":"seminar-series","term_group":0,"term_taxonomy_id":108,"taxonomy":"tribe_events_cat","description":"","parent":0,"count":57,"filter":"raw","id":108,"urls":{"self":"https:\/\/umaine.edu\/medicine\/wp-json\/tribe\/events\/v1\/categories\/108","collection":"https:\/\/umaine.edu\/medicine\/wp-json\/tribe\/events\/v1\/categories"}}],"tags":[],"venue":{"id":42507,"author":"478","status":"publish","date":"2020-09-09 09:34:19","date_utc":"2020-09-09 13:34:19","modified":"2020-09-09 09:34:19","modified_utc":"2020-09-09 13:34:19","url":"https:\/\/umaine.edu\/medicine\/venue\/virtual\/","venue":"Virtual","slug":"virtual","json_ld":{"@type":"Place","name":"Virtual","description":"","url":"https:\/\/umaine.edu\/medicine\/venue\/virtual\/","address":{"@type":"PostalAddress"},"telephone":"","sameAs":""},"show_map":true,"show_map_link":true,"global_id":"umaine.edu\/medicine?id=42507","global_id_lineage":["umaine.edu\/medicine?id=42507"]},"organizer":[{"id":42508,"author":"478","status":"publish","date":"2020-09-09 09:34:19","date_utc":"2020-09-09 13:34:19","modified":"2020-09-09 09:34:19","modified_utc":"2020-09-09 13:34:19","url":"https:\/\/umaine.edu\/medicine\/organizer\/umaine-institute-of-medicine\/","organizer":"91福利 Institute of Medicine","slug":"umaine-institute-of-medicine","phone":"207.581.3026","website":"https:\/\/umaine.edu\/medicine\/","email":"umainemed@maine.edu","json_ld":{"@type":"Person","name":"91福利 Institute of Medicine","description":"","url":"https:\/\/umaine.edu\/medicine\/","telephone":"207.581.3026","email":"u&#109;&#97;&#105;nemed&#64;&#109;ai&#110;e.ed&#117;","sameAs":"https:\/\/umaine.edu\/medicine\/"},"global_id":"umaine.edu\/medicine?id=42508","global_id_lineage":["umaine.edu\/medicine?id=42508"]}],"custom_fields":[],"json_ld":{"@context":"http:\/\/schema.org","@type":"Event","name":"Do some over-the-counter antimicrobials do more harm than good? 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