{"id":41,"date":"2017-01-16T19:00:00","date_gmt":"2017-01-17T00:00:00","guid":{"rendered":"https:\/\/umaine.edu\/kelleylab\/?page_id=41"},"modified":"2025-05-20T11:24:30","modified_gmt":"2025-05-20T15:24:30","slug":"home","status":"publish","type":"page","link":"https:\/\/umaine.edu\/kelleylab\/","title":{"rendered":"Welcome to the Kelley Lab"},"content":{"rendered":"<style>.wp-block-kadence-advancedheading.kt-adv-heading41_4d257f-1a, .wp-block-kadence-advancedheading.kt-adv-heading41_4d257f-1a[data-kb-block=\"kb-adv-heading41_4d257f-1a\"]{font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading41_4d257f-1a mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading41_4d257f-1a[data-kb-block=\"kb-adv-heading41_4d257f-1a\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading41_4d257f-1a img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading41_4d257f-1a[data-kb-block=\"kb-adv-heading41_4d257f-1a\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading41_4d257f-1a wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading41_4d257f-1a\">The Kelley Lab at the University of Maine<\/h2>\n\n\n\n<p>The Kelley Lab studies how cells track external gradients using the classic model organism, <em>Saccharomyces cerevisiae, <\/em>or as it is more commonly known, baker\u2019s or brewer\u2019s yeast.\u00a0 We are specifically interested in the spatial and temporal regulation of G-protein Coupled Receptor signaling pathways.<\/p>\n\n\n\n<p>Gradient tracking is a common process used by cells to sense and respond to their environment.&nbsp; Human cells use gradient tracking to find invading pathogens, for wound healing, for tissue development, and for cancer cell metastasis.&nbsp; Single celled organisms use gradient tracking to find food, or in the case of Baker&#8217;s Yeast, to find a mate.<\/p>\n\n\n\n<p>Despite the varied purposes for gradient tracking across a wide array of organisms, the majority of gradient tracking in eukaryotes is made possible by the same basic system of homologous proteins.\u00a0 The extracellular signal is detected by a <strong>G-protein Coupled Receptor (GPCR)<\/strong>, which turns on a signaling pathway inside the cell made up of a cellular on\/off switch called a G-protein.<\/p>\n\n\n<style>.wp-block-kadence-advancedgallery.kb-gallery-wrap-id-41_3c8bac-5d{overflow:hidden;}.kb-gallery-id-41_3c8bac-5d .kadence-blocks-gallery-item .kb-gal-image-radius, .kb-gallery-id-41_3c8bac-5d .kb-slide-item .kb-gal-image-radius img{border-radius:0px 0px 0px 0px;;}.kb-gallery-caption-style-bottom.kb-gallery-id-41_3c8bac-5d .kadence-blocks-gallery-item .kadence-blocks-gallery-item-inner .kadence-blocks-gallery-item__caption, .kb-gallery-caption-style-bottom-hover.kb-gallery-id-41_3c8bac-5d .kadence-blocks-gallery-item .kadence-blocks-gallery-item-inner .kadence-blocks-gallery-item__caption{background:linear-gradient(0deg, rgba(0, 0, 0, 0.8) 0, rgba(0, 0, 0, 0) 100%);}.kb-gallery-wrap-id-41_3c8bac-5d.wp-block-kadence-advancedgallery{overflow:visible;}.kb-gallery-wrap-id-41_3c8bac-5d.wp-block-kadence-advancedgallery .kt-blocks-carousel{overflow:visible;}<\/style><div class=\"kb-gallery-wrap-id-41_3c8bac-5d alignnone wp-block-kadence-advancedgallery\"><div class=\"kb-gallery-ul kb-gallery-non-static kb-gallery-type-carousel kb-gallery-id-41_3c8bac-5d kb-gallery-caption-style-bottom-hover kb-gallery-filter-none\" data-image-filter=\"none\" data-lightbox-caption=\"true\"><div class=\"kt-blocks-carousel splide kt-carousel-container-dotstyle-dark kt-carousel-arrowstyle-whiteondark kt-carousel-dotstyle-dark kb-slider-group-arrow kb-slider-arrow-position-center\" data-columns-xxl=\"2\" data-columns-xl=\"2\" data-columns-md=\"2\" data-columns-sm=\"2\" data-columns-xs=\"1\" data-columns-ss=\"1\" data-slider-anim-speed=\"400\" data-slider-scroll=\"1\" data-slider-arrows=\"true\" data-slider-dots=\"true\" data-slider-hover-pause=\"false\" data-slider-auto=\"\" data-slider-speed=\"7000\" data-slider-gap=\"10px\" data-slider-gap-tablet=\"10px\" data-slider-gap-mobile=\"10px\" data-show-pause-button=\"false\" data-slider-label=\"Photo Gallery Carousel\"><div class=\"splide__track\"><ul class=\"kt-blocks-carousel-init kb-gallery-carousel splide__list\"><li class=\"kb-slide-item kb-gallery-carousel-item splide__slide\"><div class=\"kadence-blocks-gallery-item\"><div class=\"kadence-blocks-gallery-item-inner\"><figure class=\"kb-gallery-figure kadence-blocks-gallery-item-has-caption\"><div class=\"kb-gal-image-radius\"><div class=\"kb-gallery-image-contain kadence-blocks-gallery-intrinsic kb-gallery-image-ratio-land32 kb-has-image-ratio-land32\" ><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/umaine.edu\/kelleylab\/wp-content\/uploads\/sites\/297\/2017\/01\/Bem1-Cdc3-animation.gif\" width=\"389\" height=\"288\" alt=\"\" data-full-image=\"https:\/\/umaine.edu\/kelleylab\/wp-content\/uploads\/sites\/297\/2017\/01\/Bem1-Cdc3-animation.gif\" data-light-image=\"https:\/\/umaine.edu\/kelleylab\/wp-content\/uploads\/sites\/297\/2017\/01\/Bem1-Cdc3-animation.gif\" data-id=\"4\" class=\"wp-image-4 skip-lazy\"\/><\/div><div class=\"kadence-blocks-gallery-item__caption\">Live Cell Yeast Microscopy<\/div><\/div><\/figure><\/div><\/div><\/li><li class=\"kb-slide-item kb-gallery-carousel-item splide__slide\"><div class=\"kadence-blocks-gallery-item\"><div class=\"kadence-blocks-gallery-item-inner\"><figure class=\"kb-gallery-figure kadence-blocks-gallery-item-has-caption\"><div class=\"kb-gal-image-radius\"><div class=\"kb-gallery-image-contain kadence-blocks-gallery-intrinsic kb-gallery-image-ratio-land32 kb-has-image-ratio-land32\" ><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/umaine.edu\/kelleylab\/wp-content\/uploads\/sites\/297\/2017\/01\/Artboard-1.png\" width=\"612\" height=\"792\" alt=\"\" data-full-image=\"https:\/\/umaine.edu\/kelleylab\/wp-content\/uploads\/sites\/297\/2017\/01\/Artboard-1.png\" data-light-image=\"https:\/\/umaine.edu\/kelleylab\/wp-content\/uploads\/sites\/297\/2017\/01\/Artboard-1.png\" data-id=\"6\" class=\"wp-image-6 skip-lazy\" srcset=\"https:\/\/umaine.edu\/kelleylab\/wp-content\/uploads\/sites\/297\/2017\/01\/Artboard-1.png 612w, https:\/\/umaine.edu\/kelleylab\/wp-content\/uploads\/sites\/297\/2017\/01\/Artboard-1-232x300.png 232w, https:\/\/umaine.edu\/kelleylab\/wp-content\/uploads\/sites\/297\/2017\/01\/Artboard-1-105x136.png 105w, https:\/\/umaine.edu\/kelleylab\/wp-content\/uploads\/sites\/297\/2017\/01\/Artboard-1-317x410.png 317w, https:\/\/umaine.edu\/kelleylab\/wp-content\/uploads\/sites\/297\/2017\/01\/Artboard-1-423x547.png 423w\" sizes=\"auto, (max-width: 320px) 85vw, (max-width: 768px) 67vw, (max-width: 1024px) 62vw,612px\" \/><\/div><div class=\"kadence-blocks-gallery-item__caption\">Computational Cell Biology<\/div><\/div><\/figure><\/div><\/div><\/li><\/ul><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>The Kelley Lab at the University of Maine The Kelley Lab studies how cells track external gradients using the classic model organism, Saccharomyces cerevisiae, or as it is more commonly known, baker\u2019s or brewer\u2019s yeast.\u00a0 We are specifically interested in the spatial and temporal regulation of G-protein Coupled Receptor signaling pathways. Gradient tracking is a [&hellip;]<\/p>\n","protected":false},"author":970,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/page-withsidebar.php","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-41","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Welcome to the Kelley Lab - Kelley Lab at 91福利 - University of Maine<\/title>\n<meta name=\"description\" content=\"Joshua Kelley&#039;s Lab at the University of Maine studies G-protein Signaling in Yeast using Computational Cell Biology, Microscopy, and Microfluidics\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/umaine.edu\/kelleylab\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Welcome to the Kelley Lab - 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