  {"id":1471,"date":"2025-06-16T10:49:20","date_gmt":"2025-06-16T14:49:20","guid":{"rendered":"https:\/\/umaine.edu\/cobre\/?post_type=tribe_events&#038;p=1471"},"modified":"2025-06-16T10:49:20","modified_gmt":"2025-06-16T14:49:20","slug":"mdi-science-cafe-worming-our-way-toward-a-better-understanding-of-neurodegenerative-disease","status":"publish","type":"tribe_events","link":"https:\/\/umaine.edu\/cobre\/event\/mdi-science-cafe-worming-our-way-toward-a-better-understanding-of-neurodegenerative-disease\/","title":{"rendered":"MDI Science Cafe: Worming Our Way Toward a Better Understanding of Neurodegenerative Disease"},"content":{"rendered":"<p>Emily Spaulding, Ph.D., The George Wojtech Endowed Chair in Neurobiology at MDIBL and a &#8220;pipeline junior faculty&#8221; in the COBRE grant team will present on June 23.<\/p>\n<p><strong>What drives neurodegenerative diseases like amyotrophic lateral sclerosis (ALS)?<\/strong><\/p>\n<p>Dr. Spaulding will discuss how her lab leverages the advantages of a transparent roundworm to better understand the contribution of disrupted cell organization to neurodegenerative conditions like ALS.<\/p>\n<p>Want to learn more about the animal models that make this research possible?<br \/>\n<a href=\"https:\/\/eml-pusa01.app.blackbaud.net\/intv2\/j\/0CB38564-6909-4763-B40F-C03998F395C6\/r\/0CB38564-6909-4763-B40F-C03998F395C6_4a73ad4a-ef03-48a3-9a60-6e932dcca7bb\/l\/1CDDCFFD-1700-44E4-A24F-C803596DC929\/c\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/eml-pusa01.app.blackbaud.net\/intv2\/j\/0CB38564-6909-4763-B40F-C03998F395C6\/r\/0CB38564-6909-4763-B40F-C03998F395C6_4a73ad4a-ef03-48a3-9a60-6e932dcca7bb\/l\/1CDDCFFD-1700-44E4-A24F-C803596DC929\/c&amp;source=gmail&amp;ust=1750165260954000&amp;usg=AOvVaw1KpFGFUSS-ToG2loYpoUnC\">Watch this reel on\u00a0<em>C. elegans<\/em>!<\/a><\/p>\n<p><em><a href=\"https:\/\/mdibl.org\/event\/worming-our-way-towards-a-better-understanding-of-neurodegenerative-disease\/?bbeml=tp-lSRWYSGFakWjDE257J90JQ.jZIWzDAlpY0e0D8A5mPOVxg.rSq1zSgPvo0iaYG6TLcynuw.lpBSIKRr-cEya0XYY7Yvaug\">Register now<\/a> to join us Monday,\u00a0June 23, 2025\u00a0at 5 p.m.<br \/>\nin\u00a0<a href=\"https:\/\/eml-pusa01.app.blackbaud.net\/intv2\/j\/0CB38564-6909-4763-B40F-C03998F395C6\/r\/0CB38564-6909-4763-B40F-C03998F395C6_4a73ad4a-ef03-48a3-9a60-6e932dcca7bb\/l\/DB9815CE-55F9-43CF-B0A2-075F40AF4FB3\/c\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/eml-pusa01.app.blackbaud.net\/intv2\/j\/0CB38564-6909-4763-B40F-C03998F395C6\/r\/0CB38564-6909-4763-B40F-C03998F395C6_4a73ad4a-ef03-48a3-9a60-6e932dcca7bb\/l\/DB9815CE-55F9-43CF-B0A2-075F40AF4FB3\/c&amp;source=gmail&amp;ust=1750165260954000&amp;usg=AOvVaw1v9lreRVfXExoJhN9U1a0s\">Maren Auditorium (#4 on map)<\/a>\u00a0or via Zoom<\/em><em>.<\/em><\/p>\n<p>The Spaulding Lab uses the optically clear nematode,\u00a0<em>C. elegans<\/em>, which contain 302 well-characterized neurons, all of which are visible in an intact, living animal. The researchers combine CRISPR\/Cas9-genetic engineering of neurodegenerative disease-associated genes with super-resolution imaging of living, adult worms to understand how disrupted cell organization leads to neuronal dysfunction.<\/p>\n<p>The Lab\u2019s goal is to uncover new therapeutic targets to treat neurodegenerative disease.<\/p>\n<p>The MDI Science Caf\u00e9\u00a0Series is brought to you by Cross Insurance<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Emily Spaulding, Ph.D., The George Wojtech Endowed Chair in Neurobiology at MDIBL and a &#8220;pipeline junior faculty&#8221; in the COBRE grant team will present on June 23. What drives neurodegenerative [&hellip;]<\/p>\n","protected":false},"author":1801,"featured_media":1473,"template":"","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_tribe_events_status":"","_tribe_events_status_reason":"","_tribe_events_is_hybrid":"","_tribe_events_is_virtual":"","_tribe_events_virtual_video_source":"","_tribe_events_virtual_embed_video":"","_tribe_events_virtual_linked_button_text":"","_tribe_events_virtual_linked_button":"","_tribe_events_virtual_show_embed_at":"","_tribe_events_virtual_show_embed_to":[],"_tribe_events_virtual_show_on_event":"","_tribe_events_virtual_show_on_views":"","_tribe_events_virtual_url":"","footnotes":""},"tags":[],"tribe_events_cat":[18,16],"class_list":["post-1471","tribe_events","type-tribe_events","status-publish","has-post-thumbnail","hentry","tribe_events_cat-event","tribe_events_cat-news","cat_event","cat_news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>MDI Science Cafe: Worming Our Way Toward a Better Understanding of Neurodegenerative Disease - Center for Biomedical Research Excellence (COBRE) - University of Maine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/umaine.edu\/cobre\/event\/mdi-science-cafe-worming-our-way-toward-a-better-understanding-of-neurodegenerative-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"MDI Science Cafe: Worming Our Way Toward a Better Understanding of Neurodegenerative Disease - Center for Biomedical Research Excellence (COBRE) - University of Maine\" \/>\n<meta property=\"og:description\" content=\"Emily Spaulding, Ph.D., The George Wojtech Endowed Chair in Neurobiology at MDIBL and a &#8220;pipeline junior faculty&#8221; in the COBRE grant team will present on June 23. 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